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本文检测 77例慢性肾衰血透患者 (HD)的胆固醇酯转运蛋白 (CETP)和血脂 ,结果显示 HD患者较对照组的 CETP、TC、HDL - C、apo AI明显降低 ,TG明显升高。按 TG分组 ,高 TG组和正常 TG组 HD患者 CETP仍显著低于对照组 ,但高 TG组 HD较正常 TG组 HD患者 TC、apo B明显升高 ,apo AI、HDL - C下降。CETP和血脂异常与 HD患者高发心、脑血管疾病密切相关 ,其发病机理需进一步探讨。
In this study, 77 patients with chronic renal failure (HD) were tested for cholesterol ester transfer protein (CETP) and lipids. The results showed that HD patients had significantly lower levels of CETP, TC, HDL - C and apo AI and higher TG than controls. According to TG group, the CETP of HD patients in high TG group and normal TG group was still lower than that of control group. However, HD and HDL in HD group were significantly higher than those in normal TG group, while apo AI and HDL - C were decreased. CETP and dyslipidemia are closely related to the high incidence of cardiovascular and cerebrovascular diseases in HD patients. The pathogenesis of CETP needs to be further explored.