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42只杂种犬按体重随机分为失血性休克组(HS)、人参二醇皂甙预治疗组(HSG)、地塞米松预治疗组(HSD)。实验过程中通过调整血容量维持平均动脉压至5.3kpa(40mmHg),定期采血测血消NE、DA、5-HT、5-HIAA及MAO的含量。结果表明:人参二醇皂甙不仅能阴止休克时NE、DA含量的增加,还能增加麻醉后NE的含量。而地塞米松只能阻止休克时NE含量的增加。人参二醇皂甙对5-HT的影响与地塞米松相同,失血3小时前5-HT含量逐渐增高,而于第4、5小时下降,提示二者均可抑制休克晚期血小板对5-HT的释放。单胺氧化酶的含量变化各组无显著差异。
Forty-two mongrel dogs were randomly divided into hemorrhagic shock group (HS), panaxodiol saponin pretreatment group (HSG) and dexamethasone pretreatment group (HSD). During the experiment, the mean arterial blood pressure was maintained at 5.3 kPa (40 mmHg) by adjusting the blood volume, and blood was collected periodically to measure the content of NE, DA, 5-HT, 5-HIAA and MAO. The results showed that: Panaxadiol saponins can not only inhibit the increase of NE, DA content, but also increase the content of NE after anesthesia. Dexamethasone can only prevent the increase of NE content during shock. The effect of panaxadiol saponin on 5-HT was similar to that of dexamethasone. The content of 5-HT gradually increased at 3 hours before blood loss and decreased at the 4th and 5th hours, suggesting that both can inhibit the late platelet response to 5-HT. freed. There was no significant difference in the content of monoamine oxidase in each group.