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目的:研究原发性高血压(EH)患者的动态动脉硬化指数(AASI)对靶器官损害的早期预测。方法:筛选无糖尿病和其他致动脉硬化性疾病的EH患者149例(EH组),以及同期健康体检者48例作为正常对照组,分别测定其体质指数、空腹血糖、血脂、肾功能,并行24 h动态血压监测及尿白蛋白/肌酐比值(ACR)测定、颈动脉内中膜厚度(IMT)测量,计算出AASI,最后进行AASI与ACR以及IMT等的相关性分析。结果:与正常对照组相比,EH组尿ACR、微量白蛋白尿发生率、IMT、颈动脉异常率以及AASI均增高(P<0.05～0.01),且EH患者的AASI与ACR以及IMT呈显著正相关。结论:EH患者的AASI与肾脏损害及颈动脉内膜损伤程度相关,可作为动脉硬化程度的评估指标。
Objective: To study the early prediction of target organ damage by dynamic arteriosclerosis index (AASI) in patients with essential hypertension (EH). Methods: A total of 149 EH patients without diabetes and other arteriosclerotic diseases (EH group) and 48 healthy controls were enrolled in this study. Their body mass index, fasting blood glucose, blood lipid and renal function were measured respectively. h dynamic blood pressure monitoring and urinary albumin / creatinine ratio (ACR) measurement, carotid intima-media thickness (IMT) measurements to calculate the AASI, the final AASI and ACR and IMT correlation analysis. Results: Compared with the control group, the urinary ACR, microalbuminuria, IMT, carotid artery abnormality rate and AASI in EH group were significantly increased (P <0.05 ~ 0.01), and the AASI, ACR and IMT in EH patients were significantly higher Positive correlation. Conclusion: AASI in EH patients is related to renal damage and carotid artery intimal injury, which can be used as an index to evaluate the degree of atherosclerosis.