丝裂素活化蛋白激酶磷酸酶是新近发现的一种双重底物特异性的蛋白磷酸酶 ,可使丝裂素活化蛋白激酶上的苏氨酸 /酪氨酸去磷酸化失活。丝裂素活化蛋白激酶磷酸酶维持血管壁的功能稳态 ,并参与对血管平滑肌细胞增殖、心肌细胞肥大及凋亡的调节 ,在心血管生理及病理生理中均发挥重要作用。 Mitochondria-activated protein kinase phosphatase is a recently discovered dual substrate-specific protein phosphatase that deactivates threonine / tyrosine dephosphorylation on the mitogen-activated protein kinase. Mitogen-activated protein kinase phosphatase maintains the homeostasis of the vascular wall and is involved in the regulation of vascular smooth muscle cell proliferation, cardiomyocyte hypertrophy and apoptosis, and plays an important role in cardiovascular physiology and pathophysiology.