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目的探讨神经生长因子低亲和力受体p75在乳腺肿瘤中的表达及其意义。方法采用PV-9000免疫组织化学方法检测101例乳腺疾病患者病灶组织中p75的表达。结果p75在乳腺肿瘤肌上皮细胞中均有表达,而在乳腺癌中的表达率明显低于纤维腺瘤、小叶增生、导管内乳头状瘤(P<0.05),各类乳腺癌中的p75表达未见明显差异(P>0.05)。结论p75可能抑制乳腺肿瘤细胞的增生,诱导瘤细胞的分化。
Objective To investigate the expression of p75, a low-affinity nerve growth factor receptor in breast cancer and its significance. Methods PV-9000 immunohistochemistry was used to detect the expression of p75 in 101 cases of breast diseases. Results The expression of p75 in breast cancer myoepithelial cells was significantly lower than that in fibroadenoma, lobular hyperplasia and intraductal papilloma (P <0.05), and the expression of p75 in various types of breast cancer No significant difference (P> 0.05). Conclusion p75 may inhibit the proliferation of breast tumor cells and induce the differentiation of tumor cells.