头孢菌素曾一度被认为仅由丝状霉菌类所产生,但现今这些重要分子也可由原核生物类如放线菌及单细胞细菌所产生。就我们所知,虽然对细菌的生物合成尚未研究;所有天然的头孢菌素的生物合成途径,在各种截然不同的微生物中都涉及由相同的酶反应形成去乙酰氧头孢菌素及去乙酰头孢菌素。 Cephalosporins were once thought to have been produced only by filamentous molds, but today these important molecules are also produced by prokaryotes such as actinomycetes and unicellular bacteria. To the best of our knowledge, although the biosynthesis of bacteria has not been studied, all the natural cephalosporin biosynthetic pathways involve the formation of deacetoxycephalosporins and deacetylases in a variety of distinct microorganisms by the same enzyme reaction cephalosporin.