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目的研究转化生长因子β1(TGF-β1)在食管癌患者血清中的水平变化,以及其与肿瘤临床分期之间的相关关系,并探讨食管癌患者手术前后TGF-β1水平的变化。方法用酶联免疫吸附试验(ELISA)方法对食管癌患者早期和晚期及正常对照者血清TGF-β1水平进行检测,同时对食管癌患者手术前后TGF-β1进行动态观察。结果食管癌患者早期和晚期血清TGF-β1水平均显著高于正常对照组(P<0.01),晚期较早期升高(P<0.01);食管癌转移组手术后血清TGF-β1水平比手术前高(P<0.01),无转移组手术后其水平较手术前明显降低(P<0.01),食管癌患者血清TGF-β1水平与肿瘤的恶性化程度有明显相关性。结论TGF-β1在食管癌发病过程中可能起着促进作用,其水平可作为食管癌病情监测的指标,同时对肿瘤的临床分期、疗效和预后的判断也有一定的帮助。
Objective To investigate the changes of TGF-β1 in serum of patients with esophageal cancer and its relationship with the clinical stage of esophageal cancer, and to explore the changes of TGF-β1 levels in patients with esophageal cancer before and after operation. Methods Serum levels of TGF-β1 in patients with esophageal cancer were detected by enzyme linked immunosorbent assay (ELISA). TGF-β1 levels in esophageal cancer patients before and after operation were also observed. Results The serum levels of TGF-β1 in early and late esophageal cancer patients were significantly higher than those in normal controls (P <0.01) and later in early esophageal cancer patients (P <0.01). The levels of serum TGF-β1 in patients with esophageal cancer were significantly higher than those before operation (P <0.01). The level of TGF-β1 in patients without metastasis was significantly lower than that before operation (P <0.01). The level of serum TGF-β1 in patients with esophageal cancer was significantly correlated with the degree of tumor malignancy. Conclusion TGF-β1 may play an important role in the pathogenesis of esophageal cancer. The level of TGF-β1 may be used as an indicator of esophageal cancer surveillance. It may also be helpful to the clinical staging, curative effect and prognosis of esophageal cancer.