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目的 :探讨转化生长因子TGFβ1、TGFβ2及其Ⅱ型受体TβRⅡ与口腔鳞癌发生和发展的关系。方法 :采用SABC免疫组化法检测 40例口腔鳞癌术后标本和 2 0例正常口腔粘膜中TGFβ1、TGFβ2及其受体TβRⅡ的表达。 结果 :口腔鳞癌和正常口腔粘膜中均表达TGFβ1、TGFβ2和TβRⅡ ,但程度不同。与正常口腔粘膜相比 ,TGFβ1、TGFβ2在口腔鳞癌中呈过表达 ,而TβRⅡ则表达下降。口腔鳞癌临床分期、有无颈淋巴结转移及病理分级与TGFβ1、TGFβ2过表达及TβRⅡ表达下降有关。 结论 :TGFβ1、TGFβ2和TβRⅡ可能参与了口腔鳞癌的发生发展及颈淋巴结转移过程 ,是口腔鳞癌发生发展及预后的一个指标。
OBJECTIVE: To investigate the relationship between TGFβ1, TGFβ2 and TβRⅡ, and the occurrence and development of oral squamous cell carcinoma. Methods: The expression of TGFβ1, TGFβ2 and TβRⅡ in 40 cases of oral squamous cell carcinoma and 20 cases of normal oral mucosa were detected by SABC immunohistochemistry. Results: Both TGFβ1, TGFβ2 and TβRⅡ were expressed in oral squamous cell carcinoma and normal oral mucosa, but with different degrees. Compared with normal oral mucosa, TGFβ1 and TGFβ2 were overexpressed in oral squamous cell carcinoma and TβRII was down-regulated. The clinical stage, presence or absence of cervical lymph node metastasis and pathological grade of oral squamous cell carcinoma are related to the over-expression of TGFβ1 and TGFβ2 and the decrease of TβRⅡ expression. Conclusion: TGFβ1, TGFβ2 and TβRⅡ may play an important role in the carcinogenesis and progression of oral squamous cell carcinoma and cervical lymph node metastasis. It is an index of the development and prognosis of oral squamous cell carcinoma.