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目的研究木通皂苷D对CCl4致小鼠急性肝损伤的保护作用。方法采用CCl4急性肝损伤模型,小鼠ig给予不同剂量的木通皂苷D(1、0.5、0.25 g·kg-1),并以水飞蓟素(0.2 g·kg-1)为阳性对照药,采用比色法检测小鼠血清的天冬氨酸转氨酶(AST)、丙氨酸氨基转移酶(ALT)及肝脏中还原性谷胱甘肽(GSH)、丙二醛(MDA)、超氧化物歧化酶(SOD)的含量。结果各剂量木通皂苷D能显著降低CCl4所致小鼠血清中AST、ALT的水平(P<0.01),同时升高肝脏组织中GSH、SOD的水平(P<0.05),降低肝脏组织中MDA的含量(P<0.05)。结论木通皂苷D对CCl4所致小鼠急性肝损伤具有显著的保护作用,其机制可能与抗氧化作用有关。
Objective To study the protective effect of samaralin D on acute liver injury induced by CCl4 in mice. Methods Acute hepatic injury model was induced by CCl4. Mice were treated with different doses of Anesthesin (0, 0.5, 0.25 g · kg-1) and silymarin (0.2 g · kg-1) Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and hepatic reductive glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD) content. Results All the doses of saponin D could significantly reduce the levels of AST and ALT in serum of CCl4 -induced mice (P <0.01) and increase the levels of GSH and SOD in liver (P <0.05) (P <0.05). Conclusion Allicin S has a significant protective effect on acute liver injury induced by CCl4 in mice, and its mechanism may be related to the anti-oxidation effect.