用电泳纯人血型糖蛋白A(GPA)制得下列衍生物:(1)用胰蛋白酶酶解GPA分离得GPA糖肽;(2)制备GPA和GPA糖肽两种抗体;(3)制备去糖GPA(dGPA);(4)用人红细胞膜全脂分别重组成含GPA及dGPA的两种脂质体。用上述制品对FCC-1/HN株恶性疟原虫裂殖子实验,发现:(1)GPA脂质体可与裂殖子结合,而dGPA脂质体呈阴性反应。(2)GPA,GPA糖肽,GPA抗体,GPA糖肽抗体及GPA脂质体均有阻止恶性疟原虫裂殖子入侵人红细胞的效应。 The following derivatives were made using electrophoretic pure human glycoprotein A (GPA): (1) GPA glycopeptide was isolated by enzymatic hydrolysis of GPA with trypsin; (2) two antibodies of GPA and GPA glycopeptide were prepared; (3) Sugar GPA (dGPA); (4) human erythrocyte membrane full-fat recombinant GPA and dGPA containing two liposomes. Using the above preparation of Plasmodium falciparum on FCC-1 / HN strain, we found that: (1) GPA liposomes can combine with merozoites and dGPA liposomes have negative reaction. (2) GPA, GPA glycopeptide, GPA antibody, GPA glycopeptide antibody and GPA liposome all have the effect of preventing P. falciparum merozoites invade human erythrocytes.