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溴化双托品铵是以阿托品为原料,合成而得的一种双季铵化合物。实验表明,家兔垂头量为0.134±0.016mg/kg;麻醉猫坐骨神经胫前肌阻断量为0.16±0.029mg/kg,作用持续21±3.9min。经典与电生理方法研究表明,它是一种非去极化型肌松药。家兔连续多次给药时有一定蓄积作用。麻醉猫快速静注给药,可使血压下降。若以缓慢静滴给药,降压作用显著减轻。对ECG则无明显影响。
Atropine bromide is a double quaternary ammonium compound synthesized from atropine. The experimental results showed that the amount of ptosis in rabbits was 0.134 ± 0.016mg / kg, the amount of blockage of tibialis anterior muscles in anesthetized cats was 0.16 ± 0.029mg / kg for 21 ± 3.9min. Classical and electrophysiological studies have shown that it is a nondepolarizing muscle relaxant. Rabbits have a number of consecutive administration of certain accumulation effect. Anesthetic cats rapid intravenous administration, can lower blood pressure. If administered intravenously slowly, the antihypertensive effect was significantly reduced. No significant effect on ECG.