论文部分内容阅读
Anthrax is a zoonotic disease caused by Bacillus anthracis.It is potentially fatal and highly contagious disease.Herbivores arc the natural host.Human acquire the disease incidentally by contact with infected animal or animal products.In the 18th century an epidemic destroyed approximately half of the sheep in Europe.In 1900 human inhalational anthrax occured sporadically in the United Stales.In 1979 an outbreak of human anthrax occured in Sverdlovsk of Soviet Union.Anthrax continued to represent a world wide presence.The incidence of the disease has decreased in developed countries as a result of vaccination and improved industrial hygiene.Human anthrax clinically presents in three forms,i.e.cutaneous,gastrointestinal and inhalational.About 95%of human anthrax is cutaneous and 5%is inhalational.Gastrointestinal anthrax is very rare(less than 1%).Inhalational form is used as a biological warefare agent. Penicillin,ciprofloxacin(and other quinolones),doxicyclin,ampicillin,imipenem.clindamycin, clarithromycin,vancomycin,chloramphenicol,rifampicin are effective antimicrobials. Antimicrobial therapy for 60 days is recommended.Human anthrax vaccine is available. Administration of anti-protective antigen(PA) antibody in combination with ciprofloxacin produced 90%-100%survival.The combination of CPG-adjuvanted anthrax vaccine adsorbed(AVA) plus dalbavancin significantly improved survival.
Anthrax is a zoonotic disease caused by Bacillus anthracis. It is potentially fatal and highly contagious disease. Herbivores arc the natural host. Human acquire the disease incidentally by contact with infected animal or animal products. The the 18th century an epidemic destroyed approximately half of the the sheep in Europe.In 1900 1900 human inhalation anthrax occured sporadically in the United Stales. In 1979 an outbreak of human anthrax occured in Sverdlovsk of the Soviet Union. Anthrax continued to represent a world wide presence. the incidence of the disease has decreased in the reporting countries as a result of vaccination and improved industrial hygiene. Human anthrax clinically presents in three forms, ie, cutaneous, gastrointestinal and inhalational. About 95% of human anthrax is cutaneous and 5% is inhalational. Gastrointestinal anthrax is very rare (less than 1%). Inhalational form is used as a biological warefare agent. Penicillin, ciprofloxacin (and other quinolones), doxicyclin, ampicillin, imipenem.clind Administration of anti-protective antigen (PA) antibody in combination with ciprofloxacin produced 90% -100% survival.The administration of anti-protective antigen (PA) antibody in combination with ciprofloxacin produced 90% -100% survival. combination of CPG-adjuvanted anthrax vaccine adsorbed (AVA) plus dalbavancin significantly improved survival.