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已经发现散发性Parkinson病 (PD)患者脑内Lewy小体(LB)中有α共和蛋白的沉积,并提出该蛋白的聚集可能参与了LB的形成及PD的发病。研究显示,α共和蛋白的过度表达具有神经毒性。另外人的变异型α共和蛋白的过度表达直接导致多巴胺神经元的死亡。1999年Engelender在筛选与α?
The deposition of α-synuclein in the brain Lewy bodies (LB) of patients with sporadic Parkinson’s disease (PD) has been found and suggests that this protein accumulation may be involved in the formation of LB and the pathogenesis of PD. Studies have shown that overexpression of α-synuclein is neurotoxic. In addition, overexpression of human variant α-synuclein directly leads to the death of dopamine neurons. 1999 Engelender in screening with α?