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目的:探讨中国海南百岁老人血清白蛋白水平与健康相关生活质量的关系。方法:本研究数据来自中国海南百岁老人队列研究2014-2016年横断面数据集，共纳入1 002名百岁老人进行问卷调查、体格检查和生物学标本检测。采用EQ-5D-VAS量表测量健康相关生活质量，采用多重线性回归和多元logistic回归分析血清白蛋白和健康相关生活质量的关联。结果:血清白蛋白与视觉模拟量表得分之间存在正向线性关系，在完全调整模型中标准化n β值为0.156（n P<0.001）。在多元logistic回归分析中，低白蛋白水平组的健康相关生活质量受损的风险是高白蛋白水平组的2.369倍（95％n CI：1.424~3.939）；性别分层分析显示，男性百岁老人中n OR=4.406（95％n CI：1.537~12.631），女性百岁老人中n OR=2.035（95％n CI：1.125~3.680）。n 结论:海南百岁老人中较低水平的血清白蛋白水平与健康相关生活质量下降有关。“,”Objective:To investigate the association between serum albumin levels and health-related quality of life in centenarians in Hainan province, China.Methods:We conducted a full sample centenarian cohort study in a community population in Hainan from 2014 to 2016, which included 1 002 centenarians for questionnaire surveys, physical examinations and biological tests. The EQ-5D-VAS scale was used to evaluate health-related quality of life, and multiple linear regression and multiple logistic regression analyses were used to analyze the association between serum albumin levels and health-related quality of life.Results:There was a positive linear relationship between serum albumin levels and EQ-5D/VAS score. The normalized n β values in the fully adjusted model was 0.156 (n P<0.001). In the multivariate logistic regression analysis, after fully adjusting the covariates, the risk of health related life quality impairment in the lower albumin group was 2.369 times(95%n CI: 1.424-3.939) than that in the higher albumin group. Gender stratified analyses showed that the n OR was 4.406 (95%n CI: 1.537-12.631) in male centenarians and 2.035 (95%n CI: 1.125-3.680) in female centenarians.n Conclusion:Lower serum albumin level was associated with impaired health-related quality of life in centenarians in Hainan.