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目的研究分析非绝经期女性冠心病患者的危险因素。方法选择2007年6月至2008年6月以冠心病或可疑冠心病住院的非绝经期女性患者157例。根据冠状动脉造影结果将其分为健康对照组(A组)和冠心病组(B组),危险因素包括血脂异常、2型糖尿病、高血压病、吸烟、早发冠心病家族史、肥胖、高尿酸血症、血清总胆红素升高、高敏C-反应蛋白(hs-CRP)升高。回顾分析冠心病组的危险因素。结果 B组与A组比较,早发冠心病家族史、吸烟史、血尿酸、血清总胆红素水平差异无统计学意义(P>0.05),高血压、糖尿病发病率明显高于A组(P<0.05),体质量指数(BMI)2组之间差异有统计学意义(P<0.05),B组甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、hs-CRP水平明显高于A组(P<0.05)。经Logistic多危因素回归分析提示,多危险因素中高甘油三酯血症为非绝经期女性冠心病最显著的独立相关危险因素,其他依次为糖尿病、高血压、hs-CRP升高、高低密度脂蛋白血症(P<0.05)。结论高血压病、2型糖尿病、脂类代谢紊乱、hs-CRP水平升高为非绝经期女性冠心病患者的危险因素,应加强对其全面认识及综合控制,从而改善患者的预后。
Objective To study the risk factors of coronary heart disease in non-menopausal women. Methods 157 patients with non-menopausal women hospitalized with coronary heart disease or suspected coronary heart disease from June 2007 to June 2008 were selected. According to the results of coronary angiography, they were divided into healthy control group (group A) and coronary heart disease group (group B). The risk factors included dyslipidemia, type 2 diabetes, hypertension, smoking, family history of premature coronary heart disease, obesity, Hyperuricemia, elevated serum total bilirubin, elevated hs-CRP. Retrospective analysis of coronary heart disease risk factors. Results There was no significant difference in family history of premature coronary heart disease, smoking history, serum uric acid and serum total bilirubin between group B and group A (P> 0.05), and the incidence of hypertension and diabetes mellitus was significantly higher than that of group A (P <0.05). There was significant difference between the two groups in body mass index (BMI) (P <0.05). The levels of triglyceride (TG), low density lipoprotein cholesterol (LDL-C), hs-CRP Obviously higher than A group (P <0.05). Logistic regression analysis of risk factors suggested that hypertriglyceridemia was the most significant independent risk factor for non-menopausal women with multiple risk factors, followed by diabetes, hypertension, elevated hs-CRP, high and low density Lipoproteinemia (P <0.05). Conclusion Hypertension, type 2 diabetes mellitus, lipid metabolism disorders and elevated hs-CRP levels are risk factors for non-menopausal women with coronary heart disease. Comprehensive understanding and comprehensive control should be strengthened to improve prognosis.