糖皮质激素(GC)与其位于细胞膜和细胞浆的受体(GR)结合后诱导恶性细胞凋亡。GR 在这一过程中起着重要作用。但有关 GR 的分布、表达与肿瘤治疗及预后关系的报道不多。我们建立了流式细胞术检测淋巴细胞 GR 的方法,以探讨 GR 表达与儿童淋巴系恶性肿瘤疾病危险度、化疗疗效及预后的关系。对象和方法1 对象 2003年2月至2004年8月上海儿童医学中心收治的初发血液系统恶性肿瘤患儿70例,其中淋巴系恶性肿 Glucocorticoid (GC) induces apoptosis of malignant cells by binding to its receptors located on the cell membrane and cytoplasm (GR). GR plays an important role in this process. However, there are few reports about the distribution and expression of GR in relation to the treatment and prognosis of cancer. We established a flow cytometry detection of lymphocyte GR method to investigate the relationship between GR expression and the risk of lymphoid malignancies in children, the efficacy and prognosis of chemotherapy. Subjects and methods 1 Subjects From February 2003 to August 2004 Shanghai Children’s Medical Center admitted to the initial hematologic malignancies in 70 cases, of which lymphoid malignancy