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作者在家兔内毒素致病理性氧供依赖性(POSD)模型上,考察氧供(Do2),氧耗量(Vo2)及血液流变学变化特点,初步探讨血液流变学改变在POSD中的作用。结果显示,在Do2-Vo2的关系中,对照组依赖段的斜率与内毒素组斜率相差显著(P<0.05).POSD时血浆粘度、纤维蛋白原浓度、红细胞聚集指数、血沉等增加,肺、骨骼肌、肾脏有较多微血栓形成,提示有弥漫性血管内凝血发生.血液粘滞性、红细胞聚集性增加,红细胞变形性降低,对微血管内血流产生严重干扰,导致组织血液灌流量不足,气体和物质交换受阻.这些改变则可能是外周组织及器官缺血甚至衰竭的原因之一.
In the rabbit model of endotoxin-induced pathology oxygen dependence (POSD), we investigated the changes of oxygen supply (Do2), oxygen consumption (Vo2) and hemorheology, and discussed the changes of hemorheology in POSD Role. The results showed that in the Do2-Vo2 relationship, the slope of the dependent segment of the control group was significantly different from the slope of the endotoxin group (P <0.05). POSD plasma viscosity, fibrinogen concentration, erythrocyte aggregation index, erythrocyte sedimentation rate increased, lung, skeletal muscle, kidney microthrombosis more, suggesting diffuse intravascular coagulation occurs. Blood viscosity, increased erythrocyte aggregation, decreased erythrocyte deformability, severe interference with microvascular blood flow, resulting in insufficient blood perfusion tissue, gas and substance exchange blocked. These changes may be one of the reasons for ischemia and even failure of peripheral tissues and organs.