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目的探讨血浆VEGF水平与子宫肉瘤血转移的关系。方法应用ELISA(酶联免疫吸附测定)法,对比分析9例子宫肉瘤患者(观察组)和20例正常人(正常组)外周血、观察组外周血和髂内静脉血、探查前和探查后切除前髂内静脉血的VEGF水平,半年后随访,了解血转移情况。结果观察组和正常组外周血、观察组外周血和髂内静脉血、探查前后髂内静脉血的VEGF水平分别为:111.58±53.42和273.60±32.58、273.60±32.58和328.47±43.62、312.12±37.57和341.34±34.35,5例血转移者(转移组)和8例无血转移者(无转移组)髂内静脉血VEGF水平为363.87±31.24和307.12±37.57,两者间均有显著差异(P<0.05)。结论子宫肉瘤患者髂内静脉血VEGF水平检测可提高其阳性率,对子宫肉瘤血转移预后的判断有重要临床意义。
Objective To investigate the relationship between the plasma VEGF level and the metastasis of uterine sarcoma. Methods The peripheral blood of 9 patients with uterine sarcoma (observation group) and 20 normal subjects (normal group) were analyzed by ELISA (enzyme linked immunosorbent assay) method. The peripheral blood and internal iliac vein blood of the observation group were compared before and after the probe The level of VEGF before resection of internal iliac vein blood, follow-up after six months to understand the blood transfer. Results The levels of VEGF in observation group and normal group, peripheral blood in observation group and internal iliac vein blood before and after exploration were 111.58 ± 53.42 and 273.60 ± 32.58, 273.60 ± 32.58 and 328.47 ± 43.62, 312.12 ± 37.57 And 341.34 ± 34.35 in 5 patients with blood metastasis (metastasis group) and 8 patients without metastasis (without metastasis group) were 363.87 ± 31.24 and 307.12 ± 37.57, respectively (P <0.05). Conclusion The detection of VEGF in uterine sarcoma can increase the positive rate of VEGF in uterine sarcoma, which has important clinical significance in judging the prognosis of uterine sarcoma.