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目的:观察维库溴铵对气管插管术中刺激反应的抑制作用。方法:将颅高压患者41例随机分为对照组20例,术前给予地西泮0.3～0.6mg·kg~(-1),iv,阿托品0.5～1.0mg,iv,利多卡因1mg·kg~(-1),iv,3min后行插管术。治疗组21例,在治疗组用药基础上再用维库溴铵4～8mg iv。观察刺激反应、循环指标、颅内血肿情况。结果:治疗组较对照组,术中术后刺激反应发生率、插管成功率,术中收缩压、氧饱和度、中心静脉压,插管术前后颅内血肿增加量,均有显著差异(P<0.05);死亡率降低差异不显著(P>0.05)。结论:维库溴铵对气管插管术中刺激反应的抑制作用强。
Objective: To observe the inhibitory effect of vecuronium on the irritation in tracheal intubation. Methods: Forty-one patients with intracranial hypertension were randomly divided into control group (20 cases), diazepam (0.3-0.6 mg · kg -1), iv, atropine 0.5-1.0 mg, iv, lidocaine 1 mg · kg ~ (-1), iv, 3min after intubation. The treatment group of 21 cases, in the treatment group based on the use of vecuronium 4 ~ 8mg iv. Observed stimulus response, circulatory index, intracranial hematoma situation. Results: Compared with the control group, the postoperative incidence of postoperative stimulation response, intubation success rate, intraoperative systolic pressure, oxygen saturation, central venous pressure, intracranial hematoma increase before and after intubation were significantly different (P <0.05), while there was no significant difference in mortality (P> 0.05). Conclusions: Vecuronium bromide has a strong inhibitory effect on the response to tracheal intubation.