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天然免疫系统发挥防御作用的关键是对病原体的识别,这一识别主要由模式识别受体(pattern recognition receptors,PRR)完成。PRR通过对病原相关分子模式(pathogen associated molecular patterns,PAMP)的识别,偶联信号传导途径,激活天然免疫细胞,最终导致一系列免疫应答的发生。
The key to the defensive effect of the innate immune system is the identification of pathogens, which is mainly performed by pattern recognition receptors (PRRs). PRR activates innate immune cells by recognizing pathogen associated molecular patterns (PAMPs) and coupling signal transduction pathways, eventually leading to a series of immune responses.