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Objective Low or moderate consumption of red wine has a greater benefit than the consumpti on of other beverages in the prevention of atherosclerosis and coronary heart di sease and this is increasingly attributed to the polyphenol compounds in red win e, such as resveratrol. In the present study, we investigated the effect of res veratrol on platelet aggregation in vitro and in vivo. Methods Platelet aggregation in rabbits and normal subjects was measured using Born’s me thod. Results Resveratrol, at 10-1000?μmol/L, significantly inhibited platelet aggregation i n vitro induced by collagen, thrombin, and ADP in healthy subjects. The inhibit ory effect was concentration-dependent. Hypercholesterolemia induced by high- cholesterol diet enhanced ADP-induced platelet aggregation. Resveratrol 4?mg ·kg -1 ·d -1 inhibited ADP-induced platelet aggregation in vivo de spite no changes in serum lipid levels. Conclusions Resveratrol inhibits platelet aggregation both in vitro and in vivo. This may b e one of the mechanisms by which resveratrol prevents atherosclerosis.
Objective Low or moderate consumption of red wine has a greater benefit than the consumpti on of other beverages in the prevention of atherosclerosis and coronary heart di sease and this is increasingly attributed to the polyphenol compounds in red win e, such as resveratrol. In the present Study, we investigated the effect of res veratrol on platelet aggregation in vitro and in vivo. Methods Platelet aggregation in rabbits and normal subjects was measured using Born’s me thod. Results Resveratrol, at 10-1000?μmol/L, significantly inhibited platelet aggregation in Inhibition of collagen, thrombin, and ADP in vitro subjects. The inhibit ory effect was concentration-dependent. Hypercholesterolemia induced by high-hyd cell diet enhanced ADP-induced platelet aggregation. Resveratrol 4?mg · kg -1 ·d -1 inhibited ADP -induced platelet aggregation in vivo de spite no changes in serum lipid levels.ConclusionResveratrol inhibits platelet aggregation both in vitro and in Vivo. This may b e one of the mechanisms by which resveratrol prevents atherosclerosis.