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随着临床应用抗-D免疫球蛋白预防胎儿骨髓成红细胞增多症以及光疗法治疗新生儿黄疸,新生儿高胆红素血症发病率已明显下降。和过去相比,作为换血指标的血清总胆红素界值的提高,使临床需要换血治疗的病例减少,医护人员临床经验不足,换血不良反应率上升,如并发感染、心跳停止和死亡等。由于近10年有关新生儿换血不良反应的风险资料缺乏,本研究调查了Clevelandd,Ohio两家新生儿围产期中心近年的新生儿换血治疗及其不良反应的发生率,并分析了换血治疗时有可能发生不良反应的危险因素。
With the clinical application of anti-D immunoglobulin to prevent fetal bone marrow polycythemia and phototherapy for neonatal jaundice, the incidence of neonatal hyperbilirubinemia has decreased significantly. Compared with the past, the increase of serum total bilirubin as an indicator of blood transfusions has reduced the number of cases requiring clinical transfusions, lack of clinical experience of medical staff and increased rates of transfusion adverse reactions, such as concurrent infection, cardiac arrest and death. Due to the lack of information on the risk of adverse reactions in neonates during the past 10 years, this study investigated the neonatal transfusions and the incidence of adverse reactions during the neonatal perinatal period in Cleveland, Ohio. Risk factors for possible adverse reactions.