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心肌细胞间的缝隙连接蛋白(Gap junction,GP)通道是其细胞间的一种特殊的蛋白连接通道,其功能主要是在细胞间起代谢偶联和电偶联作用,是心肌细胞维持电生理搏动的结构基础。近来的研究显示,心肌缝隙连接蛋白结构、功能的改变将导致心脏功能的改变,与心脏疾病的发生有密切的关系。
The Gap junction (GP) channel between cardiomyocytes is a special protein connecting channel among its cells. Its function is mainly in the metabolic coupling and electric coupling between the cells, which is the reason why the myocardial cells maintain the electrophysiological Pulsating the basis of the structure. Recent studies have shown that changes in myocardial gap junction protein structure, function will lead to changes in cardiac function, and the occurrence of heart disease are closely related.