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[目的]观察依达拉奉治疗1,2-二氯乙烷中毒性脑病的有效性和安全性。[方法]选择38例1,2-二氯乙烷中毒性脑病患者,随机分为依达拉奉治疗组和常规治疗组,治疗组在常规对症治疗的基础上,添加依达拉奉治疗,共治疗2周。对2组患者在治疗前后分别行Glasgow昏迷量表、改良Barthel指数、简易精神状态量表评估,以评定患者病情严重程度,并判断临床疗效。[结果]治疗后治疗组Glasgow昏迷量表、改良Barthel指数、简易精神状态量表评分优于对照组,差异均有统计学意义(P<0.01)。治疗组临床有效率为85.0%,高于对照组的55.6%,差异有统计学意义(P<0.05)。2组患者均未发生严重不良反应。[结论]依达拉奉治疗1,2-二氯乙烷中毒性脑病有效且安全,可促进患者神经功能恢复,改善认知能力及生活质量,提高临床疗效。
[Objective] To observe the efficacy and safety of edaravone in treating 1,2-dichloroethane toxic encephalopathy. [Method] Thirty-eight patients with 1,2-dichloroethane toxic encephalopathy were randomly divided into edaravone treatment group and conventional treatment group. The treatment group was treated with edaravone on the basis of conventional symptomatic treatment, A total of 2 weeks treatment. The Glasgow Coma Scale, Modified Barthel Index and Simple Mental Status Scale were evaluated before and after treatment to evaluate the severity of patients and the clinical efficacy. [Result] After treatment, Glasgow coma scale, modified Barthel index and simple mental status scale in treatment group were better than those in control group, with statistical significance (P <0.01). The clinical effective rate was 85.0% in the treatment group, which was higher than 55.6% in the control group, the difference was statistically significant (P <0.05). No serious adverse reactions occurred in both groups. [Conclusion] Edaravone is effective and safe in treating 1,2-dichloroethane toxic encephalopathy, which can promote the recovery of neurological function, improve cognitive ability and quality of life, and improve clinical efficacy.