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1例60岁男性患者肾癌术后自行口服索拉非尼0.2 g、2次/d。2个月后患者出现全身乏力伴巩膜黄染、尿黄。实验室检查:总胆红素(TBil)146μmol/L,直接胆红素(DBil)94μmol/L,丙氨酸转氨酶(ALT)959 U/L,天冬氨酸转氨酶(AST)1150 U/L,γ-L-谷氨酰转肽酶(γ-GT)507 U/L。停用索拉非尼,给予三磷酸胞苷二钠、还原型谷胱甘肽、腺苷蛋氨酸治疗。24 d后复查肝功能:TBil 19μmol/L,DBil 10μmol/L,ALT 54 U/L,AST 40 U/L,γ-GT 22 U/L。
A 60-year-old male patient with renal cell carcinoma was given oral sorafenib 0.2 g twice daily. Two months later, the patient developed generalized sclerosis with yellowish yellow stains and urine yellow. Laboratory tests included 146μmol / L total bilirubin (TBil), 94μmol / L DBil, 959U / L ALT, and 1150U / L AST , γ-L-glutamyl transpeptidase (γ-GT) 507 U / L. Sorafenib was discontinued and cytidine disodium triphosphate, glutathione, and adenosylmethionine were administered. Liver function was examined after 24 days: TBil 19 μmol / L, DBil 10 μmol / L, ALT 54 U / L, AST 40 U / L and γ-GT 22 U / L.