论文部分内容阅读
目的:观察慢性肾脏病Ⅴ期(CKDⅤ期)非透析患者血浆晚期氧化蛋白产物(AOPPs)水平,并探讨AOPPs与CKD患者心血管疾病(CVD)的关系。方法:对50例CKDⅤ期非透析患者(CKD组)及31例健康志愿者(对照组)进行血浆AOPPs测定。CKD组同时检测血生化指标,并使用彩色多普勒超声诊断仪检测颈动脉粥样硬化相关指标及左心室肥厚相关指标。分析AOPPs与颈动脉粥样硬化、左心室肥厚及既往CVD病史的关系。结果:CKD组血浆AOPPs水平明显高于对照组(P<0.01)。血浆AOPPs水平与颈总动脉IMT(r=0.593,P<0.01)及LVM(Ir=0.355,P<0.05)呈正相关。多元逐步回归分析,AOPPs是颈总动脉IMT(β=0.574,P<0.01)及LVM(Iβ=0.336,P<0.05)的显著相关因素。既往有CVD史的患者血浆AOPPs水平显著高于既往无CVD的患者(P<0.05)。结论:CKDⅤ期非透析患者普遍存在高AOPPs血症,AOPPs可能参与慢性肾脏病Ⅴ期非透析患者CVD的发生和发展。
Objective: To observe the level of plasma advanced oxidation protein products (AOPPs) in CKD stage Ⅴ non-dialysis patients and to investigate the relationship between AOPPs and cardiovascular disease (CVD) in patients with CKD. Methods: Plasma AOPPs levels were measured in 50 cases of non-dialysis CKD patients (CKD group) and 31 healthy volunteers (control group). CKD group also detected blood biochemical markers, and the use of color Doppler ultrasound diagnosis of carotid atherosclerosis related indicators and related indicators of left ventricular hypertrophy. The relationship between AOPPs and the history of carotid atherosclerosis, left ventricular hypertrophy and previous CVD was analyzed. Results: Plasma AOPPs level in CKD group was significantly higher than that in control group (P <0.01). Plasma AOPPs levels were positively correlated with carotid artery IMT (r = 0.593, P <0.01) and LVM (Ir = 0.355, P <0.05). Multivariate stepwise regression analysis showed that AOPPs were significantly associated with common carotid artery IMT (β = 0.574, P <0.01) and LVM (Iβ = 0.336, P <0.05). Plasma AOPPs levels were significantly higher in patients with previous CVD history than in previous CVD-free patients (P <0.05). Conclusion: AOPPs are common in CKD stage Ⅴ non-dialysis patients. AOPPs may be involved in the occurrence and development of CVD in stage 非 non-dialysis patients with chronic kidney disease.