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目的探讨人工肝联合内科治疗重型肝炎例短期预后效果。方法选取2012年l2月—2015年l2月就诊的72例重型肝炎患者,随机分为研究组和对照组各36例,研究组接受人工肝联合内科综合治疗,对照组给予单纯内科综合治疗,观察两组入院时和治疗3个月后凝血酶原时间的国际标准化比率(international normalized ratio,INR)、总胆红素(totalbilirubin,TBIL)和血清肌酐(creatinine,Cr),计算终末期肝病模型(modelforend-stageliverdisease,MELD)分值,数据采用SPSS17.0进行统计学分析,P<0.05为差异有统计学意义。结果研究组治疗前后TBIL和INR比较差异均有统计学意义(t=2.014、4.576,P<0.05),且治疗后INR优于对照组,比较差异有统计学意义(t=3.235,P<0.05);治疗后研究组和对照组20≤MELD<30和30≤MELD<40的评分均低于治疗前(均P<0.05),且研究组优于对照组,比较差异均有统计学意义(t=2.278、2.860,均P<0.05)。结论人工肝联合内科治疗重型肝炎例短期预后效果良好,值得临床推广使用。
Objective To investigate the short-term prognosis of patients with severe hepatitis treated by artificial liver combined with internal medicine. Methods Seventy-two patients with severe hepatitis treated from January 2012 to February 2016 were randomly divided into study group and control group with 36 cases each. The study group received artificial liver combined with internal medicine and the control group received simple internal medicine treatment. The observation group The international normalized ratio (INR), totalbilirubin (TBIL) and creatinine (Cr) of prothrombin time at the time of admission and 3 months after treatment were used to calculate the end-stage liver disease model modelforend-stageliverdisease, MELD) scores, the data using SPSS17.0 for statistical analysis, P <0.05 for the difference was statistically significant. Results Before and after treatment, the levels of TBIL and INR in the study group were significantly different (t = 2.014, 4.576, P <0.05), and after treatment, INR was better than the control group, the difference was statistically significant (t = 3.235, P <0.05 ). After treatment, the scores of 20≤MELD <30 and 30≤MELD <40 in study group and control group were lower than those before treatment (all P <0.05), and the study group was superior to the control group with significant difference t = 2.278,2.860, all P <0.05). Conclusion The artificial liver combined with medical treatment of severe hepatitis has a good short-term prognosis and is worthy of clinical promotion.