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Objective: To investigate DNA-dependent protein kinase (DNA-PK) expression,and its relationship with lymphat-ic metastasis in colorectal cancer. Methods: Tumor tissues from 60 patients,divided into two groups according to lymphatic metastasis,were immunohistochemically stained to detect the DNA-PK expression including Ku70,Ku80 and PKcs proteins. Results: Positivity of both Ku70 and Ku80 in colorectal cancer was negatively correlated with lymphatic metastasis with an r value of -0.57 and -0.38,respectively. Similar correlation was found between Ku expression,especially Ku70,and long-term survival. PKcs,however,displayed no significant correlation. Statistical analysis failed to detect any correlation between DNA-PK expression,and clinical characteristics,such as age,sex,tumor location,tumor thickness and distant metastasis (P>0.05). Conclusion: DNA-PK expression,especially Ku70 expression,is negatively correlated with lymphatic metastasis,and the survival of patients with colorectal cancer. Ku70 expression may be a potential indicator for the preoperative evaluation,and prognosis in colorectal cancer.
Objective: To investigate DNA-dependent protein kinase (DNA-PK) expression, and its relationship with lymphat-ic metastasis in colorectal cancer. Methods: Tumor tissues from 60 patients, divided into two groups according to lymphatic metastasis, were immunohistochemically stained to detect The DNA-PK expression including Ku70, Ku80 and PKcs proteins. Results: Positivity of both Ku70 and Ku80 in colorectal cancer was negatively correlated with lymphatic metastasis with an r value of -0.57 and -0.38, respectively. Similarityally found between Ku expression , especially Ku70, and long-term survival. PKcs, however, displayed no significant correlation. Statistical analysis failed to detect any correlation between DNA-PK expression, and clinical characteristics, such as age, sex, tumor location, tumor thickness and distant metastasis (P> 0.05). Conclusion: DNA-PK expression, especially Ku70 expression, is negatively correlated with lymphatic metastasis, and the survival of patients with colorectal ca ncer. Ku70 expression may be a potential indicator for the preoperative evaluation, and prognosis in colorectal cancer.