论文部分内容阅读
目的探究利福平和利福喷丁对肺结核患者病灶吸收及痰液细菌转阴的影响,为临床肺结核治疗提供可靠依据。方法选取正阳县人民医院82例肺结核患者,依据随机数字表法分组,每组41例。两组均给予异烟肼、吡嗪酰胺、盐酸乙胺丁醇治疗,于此基础上对照组加用利福平治疗,观察组加用利福喷丁治疗,均治疗3个月。对比两组病灶吸收率、临床疗效并随访3个月统计痰液细菌转阴率。结果治疗3个月后,观察组病灶吸收率(92.68%)高于对照组(73.17%),差异有统计学意义(P<0.05);观察组总有效率(90.24%)优于对照组(60.98%),差异有统计学意义(P<0.05);观察组治疗后1个月、3个月痰液细菌转阴率均较对照组提高,差异有统计学意义(P<0.05)。结论对肺结核患者应用利福喷丁治疗效果显著,可促进患者病灶吸收,且有利于痰液细菌转阴,效果优于利福平。
Objective To investigate the effect of rifampicin and rifapentine on the absorption of lesions in patients with pulmonary tuberculosis and sputum bacterial negative conversion, providing a reliable basis for clinical treatment of pulmonary tuberculosis. Methods 82 patients with pulmonary tuberculosis in Zhengyang People’s Hospital were selected and divided into groups according to the random number table method, with 41 cases in each group. Both groups were given isoniazid, pyrazinamide, ethambutol hydrochloride treatment, on the basis of the control group plus rifampin treatment, the observation group plus rifapentine treatment, were treated for 3 months. Compare the absorption rate of two groups of lesions, clinical efficacy and follow-up of sputum bacterial conversion rate of 3 months. Results After 3 months of treatment, the absorptive rate in the observation group (92.68%) was higher than that in the control group (73.17%) (P <0.05). The total effective rate (90.24%) in the observation group was better than that in the control group 60.98%, respectively), the difference was statistically significant (P <0.05). The sputum bacterium negative conversion rate in the observation group was higher than that in the control group at 1 month and 3 months after treatment, the difference was statistically significant (P <0.05). Conclusion The application of rifapentine in patients with tuberculosis has significant therapeutic effect, which can promote the absorption of the lesion in patients and is conducive to sputum bacterial negative conversion, which is superior to rifampicin.