采用ＰＣＲ－ＳＳＣＰ法，检测胰腺癌和慢性胰腺炎组织的ＡＰＣ基因突变。结果：１２例胰腺癌中有３例发生ＡＰＣ基因突变，慢性胰腺炎无ＡＰＣ基因异常改变。提示胰腺癌的发生发展过程与ＡＰＣ基因失活有关 PCR-SSCP was used to detect APC gene mutations in pancreatic cancer and chronic pancreatitis. RESULTS: APC gene mutations occurred in 3 of 12 cases of pancreatic cancer, and there was no abnormal APC gene change in chronic pancreatitis. Suggests that the development of pancreatic cancer is related to the inactivation of APC gene