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目的:研究RAB5A基因的高表达在乳腺癌发生发展及转移与预后中的作用。方法:对牡丹江市肿瘤医院2003-01/1246例乳腺癌术后标本,应用免疫组化技术检测RAB5A基因的表达。结果:RAB5A的表达在正常组织中不表达,而在乳腺癌组织中有不同程度的表达(P<0.01)。结论:RAB5A是一个可能与乳腺癌发生、转移相关的基因,并且还可能与它们的分化程度有关。
Objective: To investigate the role of RAB5A gene overexpression in the development, metastasis and prognosis of breast cancer. Methods: The specimens of breast cancer from 2003-01 / 1246 in Mudanjiang Tumor Hospital were detected by immunohistochemistry to detect the expression of RAB5A gene. Results: The expression of RAB5A was not expressed in normal tissues but different in breast cancer tissues (P <0.01). Conclusion: RAB5A is a gene that may be involved in the occurrence and metastasis of breast cancer, and may also be related to their differentiation degree.