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雌激素不仅在生殖系统,而且在多个系统中发挥着广泛且重要的作用。近来许多研究证实,除了传统的介导基因组信号通路的雌激素受体(ER)-ERα和ERβ外,还存在着新型的调节非基因组信号的ER-G蛋白偶联受体30(GPR30),它能够参与多种细胞的众多生理病理过程。尽管它们有时存在交叉作用,但GPR30的功能与经典受体明显不同,它在雌激素相关疾病发病机制中的作用逐渐成为国内外学者研究的热点。
Estrogen plays a broad and important role not only in the reproductive system, but also in multiple systems. Recently, many studies have shown that in addition to the traditional estrogen receptor (ER) -ERα and ERβ that mediate the genomic signaling pathway, there is a new type of ER-G protein-coupled receptor 30 (GPR30) that regulates non-genomic signals, It is capable of participating in a wide range of physiological and pathological processes in a variety of cells. Despite their sometimes cross-functional effects, GPR30 functions significantly differently from classical receptors, and its role in the pathogenesis of estrogen-related diseases has gradually become a hot topic both at home and abroad.