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目的:观察血小板单采术联合药物治疗原发性血小板增多症(ET)的效果。方法:将ET40例随机分为观察组和对照组各20例。对照组给予羟基脲、抑制血小板聚集药物及改善微循环药物治疗;观察组行血小板单采术后,按照对照组用药方案进行治疗,比较两组疗效。结果:观察组高黏滞血症改善和血小板恢复正常所需时间分别为(2.5±1.2)天和(6.75±1.3)天,对照组分别为(7.5±1.1)天和(19.6±4.5)天,两组比较,差异非常显著(P<0.01)。结论:血小板单采术联合药物治疗ET效果显著,且可缩短治疗时间。
Objective: To observe the effect of thrombocytopenia combined with medication on essential thrombocythemia (ET). Methods: ET40 cases were randomly divided into observation group and control group, 20 cases each. The control group was given hydroxyurea, inhibition of platelet aggregation drugs and improve microcirculation drug treatment; observation group were treated with platelet apheresis, according to the control group medication regimen, the efficacy of the two groups were compared. Results: The time required for improvement of hyperviscosity and platelet recovery in the observation group was (2.5 ± 1.2) days and (6.75 ± 1.3) days, respectively, and that in the control group was (7.5 ± 1.1) and (19.6 ± 4.5) days , The difference between the two groups was significant (P <0.01). Conclusion: The combination of platelet apheresis and ET can significantly reduce the treatment time.