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第五届国际毒理学大会(V International Congress of Toxicology)由国际毒理学联合会主办,于1989年7月16～21日在英国Brighton市召开,有来自50个国家和地区的1300名代表参加。笔者应邀出席了大会。 本届大会交流内容广泛。首先,反映了器官毒理学正向细胞及分子水平发展。大会共收到论文200余篇,涉及肾脏、肝脏、神经、肺脏、心血管、皮肤、生殖等器官的毒理学。在肾脏毒理方面,应用了大鼠离体肾单位或肾近曲小管上皮细胞培养的模型,观察毒物影响细胞膜功能、细胞内ATP、Ca~(2+)、脂质过氧化、肾素—血管紧张素、肾组织中金属硫蛋白以及尿中酶和低分子蛋白等的变化。肝脏毒理研究方面利用了肝灌流模型及培养的离
The Fifth International Toxicology Conference (V International Congress of Toxicology), organized by the International Toxicology Association, was held on July 16-21, 1989 in Brighton, England, with 1,300 delegates from 50 countries and regions. The author was invited to attend the conference. The current exchange of broad content. First, it reflects the positive development of organ toxicology at the cellular and molecular level. The conference received a total of 200 papers, involving the kidneys, liver, nerves, lungs, cardiovascular, skin, reproductive organs and other toxicology. In the aspects of renal toxicology, the model of rat renal tubular epithelial cell culture or renal proximal tubule epithelial cell culture was used to observe the effect of toxicant on cell membrane function, intracellular ATP, Ca 2+, lipid peroxidation, renin- Angiotensin, metallothionein in renal tissue and urinary enzymes and low molecular weight proteins. Hepatotoxicity studies utilize the model of liver perfusion and culture