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观察前列腺素Ｅ２（ＰＧＥ２）凝胶用于足月妊娠的促宫颈成熟与引产作用，评价其对母儿的安全性。方法选择１００例足月妊娠有引产指征的未产妇，随机分为两组，ＰＧＥ２组５０例，硫酸普拉酮钠（ＤＨＡ－Ｓ）组５０例，分别于用药后（即停药次日）检查宫颈评分的变化，观察两组对宫颈促熟作用及各项产科参数。结果ＰＧＥ２凝胶具有明显的促宫颈成熟作用，显效率及自然临产率优于ＤＨＡ－Ｓ组（Ｐ＜０．０１），减少了催产素用量（Ｐ＜０．０１），缩短了引产至临产的时间。结论ＰＧＥ２凝胶单次宫颈管应用具有促宫颈成熟和引产作用，且安全、有效、方便
Prostaglandin E2 (PGE2) gel was used to promote cervical maturation and induction of labor in full-term pregnancy to evaluate its safety for both mother and child. Methods One hundred pregnant women with full-term pregnancy who had induction of labor induction were randomly divided into two groups: 50 in PGE2 group and 50 in DHA-S group, ) Check the cervical score changes, observe the two groups on the role of cervical ripening and various obstetrical parameters. Results PGE2 gel had obvious effect of promoting cervical ripening, and the effective rate and spontaneous labor rate were superior to DHA-S group (P <0.01), and the dose of oxytocin was decreased (P <0.01) time. Conclusions Single cervical canal application of PGE2 gel can promote cervical ripening and induction of labor and is safe, effective and convenient