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目的：探讨ＣＤ４４（ＣＤ４４ｓ及ＣＤ４４ｖ６）和ｎｍ２３基因产物表达与食管癌临床病理指标及预后的关系。方法：应用ＳＰ免疫组化染色法对５４例食管癌标本进行ＣＤ４４、ｎｍ２３基因产物测定，并对其中４１例进行了术后３年随访。结果：ＣＤ４４ｖ６基因产物的高表达和ｎｍ２３基因产物的低表达与食管癌的浸润转移、复发和预后均有关（Ｐ＜００５）。食管癌中ＣＤ４４ｖ６和ｎｍ２３表达呈负相关。ＣＤ４４ｖ６阳性伴ｎｍ２３阴性表达的患者发生淋巴结转移的可能性大。结论：ＣＤ４４（尤其是ＣＤ４４ｖ６）和ｎｍ２３在食管癌中的表达与食管癌的发生发展、浸润转移和预后密切相关，ＣＤ４４ｖ６和ｎｍ２３表达在食管癌淋巴结转移中起协同作用，可作为临床预测浸润转移和估计预后的一个重要参考指标。
Objective: To investigate the relationship between the expression of CD44 (CD44s and CD44v6) and nm23 gene products and clinicopathological parameters and prognosis of esophageal cancer. Methods: SP immunohistochemical staining was used to detect the expression of CD44 and nm23 genes in 54 specimens of esophageal cancer, and 41 of them were followed up for 3 years. RESULTS: High expression of CD44v6 gene product and low expression of nm23 gene product were associated with invasion, metastasis, recurrence, and prognosis of esophageal cancer (P < 0.05). There was a negative correlation between the expression of CD44v6 and nm23 in esophageal cancer. Patients with CD44v6 positive with nm23-negative expression are more likely to have lymph node metastasis. Conclusion: The expression of CD44 (especially CD44v6) and nm23 in esophageal cancer is closely related to the occurrence, development, infiltration, metastasis and prognosis of esophageal cancer. The expression of CD44v6 and nm23 may play a synergistic role in lymph node metastasis of esophageal cancer and can be used as a predictor of clinical invasion. And an important reference for estimating the prognosis.