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目的观察分析丙种球蛋白及干扰素治疗手足口病合并病毒性脑炎临床疗效。方法将该院2014年11月—2016年11月收治的64例手足口病合并病毒性脑炎的患儿作为研究对象,并将其随机分为对照组和观察组,对对照组的患儿采用临床中的常规治疗方法进行治疗,对观察组在对采用丙种球蛋白及干扰素药物进行治疗,在进行一段时间后,观察并记录两组患儿在治疗过程中的症状变化程度和症状的改善时间,以及随时记录患儿在治疗中并发症的发生情况,对两组患儿进行为期3个月的随访调查,观察疾病的复发情况,用于判断丙种球蛋白联合干扰素在治疗手足口病合并病毒性疾病中的临床效果。结果在一段时间的治疗后,两组患儿的症状均得到了一定程度上的改善,但是观察组患儿的症状改善程度要远远高于对照组;观察组患儿病情改善所用时间也要远远短于对照组;根据对两组患儿在治疗过程中的并发症的发生几率进行记录发现,观察组患儿的并发症的发生几率显著低于对照组,两组数据差异有统计学意义(P<0.05)。结论丙种球蛋白联合干扰素在治疗手足口病合并病毒性脑炎疾病的治疗中效果相较于常规治疗方法更为显著,再确保显著疗效的同时,降低了患儿并发症的发生几率以及疾病的复发率,有效提高了患儿的存活率,值得临床推广应用。
Objective To investigate the clinical efficacy of gamma globulin and interferon in the treatment of hand, foot and mouth disease with viral encephalitis. Methods A total of 64 children with HFMD and viral encephalitis admitted to our hospital from November 2014 to November 2016 were selected as study subjects and randomly divided into control group and observation group. Using clinical routine treatment for treatment, the observation group in the use of gamma globulin and interferon drugs for treatment, after a period of time to observe and record the two groups of children in the course of treatment of symptoms and degree of symptoms Improve time, and record the incidence of complications in children at any time, two groups of children for a period of 3 months of follow-up survey to observe the recurrence of the disease for the determination of gamma globulin combined with interferon in the treatment of hand, foot and mouth Clinical effect in the complication of viral diseases. Results After a period of treatment, the symptoms of both groups were improved to a certain extent, however, the symptom improvement in the observation group was much higher than that in the control group. The time spent in improving the observation group was also Is far shorter than the control group; According to the two groups of children in the course of treatment of complications occurred in the probability of recording found that the incidence of complications in observation group was significantly lower than the control group, the two groups were statistically significant differences Significance (P <0.05). Conclusions The effect of gamma globulin combined with interferon on the treatment of hand, foot and mouth disease combined with viral encephalitis is more significant than that of conventional treatment, so as to ensure significant curative effect and reduce the incidence of complications and diseases Of the recurrence rate, effectively improve the survival rate of children, it is worth promoting the clinical application.