随着医学科学技术的飞速发展,第三次疫苗革命——核酸疫苗正在悄然兴起,呈现出令人鼓舞的应用前景。 第三次疫苗革命始于1990年。Wolff在基因治疗工作中发现,DNA以质粒形式注入小鼠肌肉,用检测酶的方法能证明其在肌肉组织中表达,并可持续数月,甚至终生,且未发现DNA整合到宿主细胞染色体中。随后,Willi- With the rapid development of medical science and technology, the third vaccine revolution - nucleic acid vaccine is quietly rising, showing encouraging application prospects. The third vaccine revolution began in 1990. Wolff found in gene therapy work that DNA is injected into the muscle of mice as a plasmid and that it can be demonstrated in muscle tissue using the enzyme-detection method and can last for months or even lifetime without any integration of DNA into the host cell chromosome . Subsequently, Willi-