自从紫杉醇广泛应用于临床治疗以来,与微管作用的抗肿瘤天然产物的发现、化学修饰和机制研究已经成为学术和临床研究的热点。介绍了与微管作用的抗肿瘤天然产物的研究情况,包括紫杉醇、埃博霉素、disco-dermolid、考布他汀、软海绵素、海兔毒素、那可丁等,简要探讨了目前存在的问题和未来的发展方向。 Since the widespread use of paclitaxel in clinical treatment, the discovery, modification and mechanism of anti-tumor natural products with microtubules have become hot spots in academic and clinical research. The research status of anti-tumor natural products interacting with microtubules is introduced, including paclitaxel, epothilone, disco-dermolid, combretastatin, cortin, dolastatin and nocetine. Problems and future direction of development.