十二指肠溃疡的病因和发病机制尚不十分清楚。现在认为,消化性溃疡起因于胃酸生成与粘膜抵抗力之间的平衡失调。十二指肠溃疡的发病因素中幽门螺杆菌(HP)起着主要作用。事实上,这类患者中几乎百分之百都存在 HP,抗生素的治疗通过杀灭 HP 使溃疡完全愈合。然而,由微生物引起溃疡形成的机制尚 The etiology and pathogenesis of duodenal ulcer is not yet clear. It is now believed that peptic ulcer arises from a dysregulation of balance between gastric acid production and mucosal resistance. Helicobacter pylori (HP) plays a major role in the pathogenesis of duodenal ulcer. In fact, nearly 100% of these patients have HP, and the antibiotic treatment heals the ulcer completely by killing HP. However, the mechanism of ulcer formation caused by microorganisms remains