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纳米金(GNPs)是一种新型纳米材料,现被广泛用于各个学科的研究。在医学领域,GNPs材料在肿瘤诊断与治疗方面的研究已成为热点,其放射增敏作用在国内外已有一些文献报道。Herold等[1]发现将GNPs颗粒与肿瘤细胞混合或注射至肿瘤组织中,使用光子束照射后,与对照组比较,表明GNPs能够增加生物有效剂量,首次发现了GNPs材料的放射增敏作用。而近年来随着GNPs微粒研究的深入,放射增敏相关的研究也越来越多。研究者发现GNPs在MCF-7乳腺癌细胞系[2]、DU-145前列腺癌细胞系[3]和HeLa宫颈癌细胞系[4]等和一些肿瘤动物模型[5]中均具有放射增敏现象。目前研究表明GNPs这一新型材料相较一些常用的化学增敏剂,如氟尿嘧啶[6]、吉西他滨[7]等,不仅具有良好的放射增敏效果,而且可以作为抗肿瘤药物的载体,为肿瘤治疗的靶向性和高效性提供条件。本文就GNPs材料放射增
Nanogolds (GNPs), a new type of nanomaterial, are now widely used in various disciplines. In the field of medicine, the research of GNPs in tumor diagnosis and treatment has become a hot spot, and its radiosensitization has been reported in the literature both at home and abroad. Herold et al. [1] found that GNPs particles were mixed with tumor cells or injected into tumor tissue. Compared with the control group, GNPs could increase the bio-effective dose by photon beam irradiation, and the radiosensitization of GNPs was first discovered. In recent years, with the further study of GNPs particles, more and more studies related to radiosensitization. The researchers found that GNPs have radiosensitization in MCF-7 breast cancer cell lines [2], DU-145 prostate cancer cell lines [3] and HeLa cervical cancer cell lines [4], and some tumor animal models [5] phenomenon. The current research shows that compared with some commonly used chemosensitizers such as fluorouracil [6], gemcitabine [7], this novel material not only has good radiosensitizing effect, but also can be used as a carrier of anti-tumor drugs for tumors Targeted and efficient treatment provides the conditions. This article on the GNPs material radioactive increase