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许多临床试验证明外用非甾体抗炎药(NSAID)比安慰剂有更显著的疗效。1980～1992年,在英国外用NSAID的处方总量上升了115倍多。过去4年新的制剂增加了384％。 外用布洛芬霜后2～4小时血浆浓度达到峰值,优洛芬6小时达峰值,苯达明则24～32小时达峰值。外用布洛芬、felbinac后的皮下脂肪、肌肉和滑膜液的组织浓度远远高于它们直接吸收的血浆浓度。优洛芬、felbinac的滑膜液中浓度高于血浆浓度,而炎痛喜康、diclofenac则和血浆浓度相等或低于血浆浓度。
Many clinical trials have shown that topical NSAIDs have a more pronounced effect than placebo. Between 1980 and 1992, the total number of prescriptions for topical NSAIDs in the United Kingdom increased more than 115-fold. New formulations have increased 384% over the past four years. Topical concentrations of ibuprofen peaked at 2 to 4 hours after topical use of ibuprofen, with peaks at 6 hours for upliprofen and up to 24 to 32 hours for benzodamine. Topical ibuprofen, felbinac subcutaneous fat, muscle and synovial fluid tissue concentrations far higher than their direct absorption of plasma concentrations. The concentrations of iloprofen and felbinac in synovial fluid were higher than those in plasma, whereas indomethacin and diclofenac were equal to or lower than plasma concentrations.