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目的 :探讨心钠素 (ANP)在新生儿缺氧缺血性脑病 (HIE)合并低钠血症中所起的作用及其临床意义。方法 :应用放射免疫法检测 46例 HIE患儿生后 2天、7天血浆 ANP的含量 ,同时检测了血清钠的含量 ,并与 2 0例健康足月儿对照。结果 :(1) HIE急性期血浆 ANP水平比正常对照组明显增高 (P<0 .0 1)。(2 ) HIE急性期血浆 ANP水平与 HIE程度密切相关 ,HIE越重 ,ANP水平越高 ;血浆 ANP水平越高 ,血清钠的水平越低 ,二者呈负相关 (r=- 0 .81,P<0 .0 1)。结论 :ANP可能参与 HIE体内水盐调节过程 ,HIE患儿可合并失钠性低钠血症。治疗上要强调纠正缺氧、酸中毒 ,限制液体量 ,适当补充钠盐
Objective: To investigate the role and clinical significance of atrial natriuretic peptide (ANP) in neonates with hypoxic-ischemic encephalopathy (HIE) complicated with hyponatremia. Methods: The plasma levels of ANP in 46 HIE children at 2 days and 7 days after birth were detected by radioimmunoassay. Meanwhile, the serum sodium level was detected and compared with 20 healthy full-term infants. Results: (1) The level of plasma ANP in acute phase of HIE was significantly higher than that of normal control group (P <0.01). (2) The level of plasma ANP in HIE was closely related to the level of HIE, the more HIE was, the higher the level of ANP. The higher the level of plasma ANP was, the lower the level of serum sodium was (r = -0.881, P <0 .0 1). Conclusion: ANP may be involved in the process of water and salt regulation in HIE. HIE may be associated with sodium-reduced hyponatremia. Treatment should be emphasized to correct hypoxia, acidosis, limit the amount of liquid, appropriate sodium supplementation