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目的研究人类免疫缺陷病毒1型(HIV-1)感染者中乙型肝炎病毒(HBV)和(或)丙型肝炎病毒(HCV)感染的流行现状及其特点。方法对上海市(复旦大学附属)公共卫生中心就诊的170例HIV-1感染者采集血标本,使用微粒子酶联免疫法(MEIA)检测HIV-1感染者血清的乙型肝炎二对半(HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc),应用酶联免疫吸附试验(ELISA)检测HCV抗体。结果170名HIV-1感染者中,男性146人,女性24人,最小年龄16岁,最大年龄74岁,平均年龄41±13岁;HBsAg阳性患者19人(11．2％),抗-HBs阳性者87人(51．2％),HBeAg阳性者7人(4．1％)．抗-HBe阳性者49人(28．8％),抗-HBc阳性者111人(65．2％);抗-HCV阳性者77人(45．3％)。HIV-1、HBV和HCV三重感染者9人,约占5．3％。结论HIV-1感染者HBsAg阳性率与普通人群相近,但HIV-1与HCV混合感染的比例显著高于普通人群。
Objective To study the prevalence and characteristics of hepatitis B virus (HBV) and / or hepatitis C virus (HCV) infection in human immunodeficiency virus type 1 (HIV-1) infected persons. Methods Blood samples were collected from 170 HIV-1 infected patients attending the Public Health Center of Shanghai (Fudan University Affiliated Public Health Center). Serum samples of hepatitis B virus (HBsAg) were detected by MEIA , Anti-HBs, HBeAg, anti-HBe, anti-HBc), HCV antibodies were detected by enzyme linked immunosorbent assay (ELISA). Results Of 170 HIV-1 infected persons, there were 146 males and 24 females, the youngest was 16 years old, the oldest was 74 years old, with an average age of 41 ± 13 years; 19 HBsAg positive patients (11.2%), anti-HBs 87 were positive (51.2%) and 7 were HBeAg-positive (4.1%). 49 were anti-HBe positive (28.8%), 111 were anti-HBc positive (65.2%) and 77 were anti-HCV positive (45.3%). HIV-1, HBV and HCV triple infection 9, accounting for about 5.3%. Conclusion The positive rate of HBsAg in HIV-1 infection is similar to that in the general population, but the proportion of HIV-1 and HCV infection is significantly higher than that of the general population.