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目的探讨不同程度动脉粥样硬化 (AS)症患者血浆内皮素 (ET)、一氧化氮 (NO)的水平 ,区分出轻、中、重AS症内皮素、一氧化氮范围 ,为了解AS的程度并进一步佐证内皮素、一氧化氮在AS中的作用提供依据。方法用脑阻抗图硝酸甘油试验、颈动脉脑循环动力学超声检测眼底动脉AS及其程度并作内皮素、一氧化氮测定。结果内皮素在轻度AS组为 4 2 .5 5～ 73.15pg/ml,中度AS组 为 4 2 .76～ 10 1.93pg/ml,重度AS组为 85 .2 7～ 131.19pg/ml;一氧化氮在轻度AS组为 4 5 .9～ 5 9.6 μmol/L ,中度AS组为35 .6 2～ 4 6 .3μmol/L,重度AS组为 2 8.6 9～ 39.96 μmol/L。 结论内皮素、一氧化氮测定可作为判断AS程度的一种简易、方便的定量指标。
Objective To investigate the levels of plasma endothelin (ET) and nitric oxide (NO) in patients with different degree of atherosclerosis (AS) and to distinguish the range of endothelin and nitric oxide in light, moderate and severe AS, And further evidence of endothelin, nitric oxide in the role of AS provide the basis. Methods Brain impedance map nitroglycerin test, carotid artery circulation dynamics ultrasound detection of fundus arteries AS and its extent and for the determination of endothelin, nitric oxide. Results Endothelin was 42.55 ~ 73.15pg / ml in mild AS group, 42.76 ~ 10.193pg / ml in moderate AS group and 85.27 ~ 131.19pg / ml in severe AS group. Nitric oxide was between 45.59 and 59.6 μmol / L in mild AS group, 35.62 ~ 46.3 μmol / L in moderate AS group and 22.66 ~ 39.96 μmol / L in severe AS group. Conclusion The determination of endothelin and nitric oxide can be used as a simple and convenient quantitative index to judge the degree of AS.