目的探讨高氧液输注的安全性、有效性及对重症烧伤患者血清丙二醛水平的影响。方法选择伤后72h以内入院、烧伤体表总面积(total burns surface area,TBSA)在30%以上、伤前无严重疾患、年龄18～65岁的重症烧伤30例,随机分为治疗组及对照组,每组15例。两组均按“四早”方案治疗,在此基础上治疗组在静脉补液时以500 ml×4/24 h的高氧液代替等量的常规液体补入,对照组输注常规液体。两组均于输注高氧液前及输注后的24 h、48 h、72 h分别采集血标本,用比浊法测定血清丙二醛含量。并于采集血标本的同一时间点,记录各病例的一般情况,包括:体温、呼吸、心率,经股动脉采集动脉血送检血气分析。数据以±s表示,采用PEMS 3.1统计分析软件进行t检验。结果两组病例的一般情况:体温、呼吸、心率在输注高氧液前后的各时间点比较无差异(P>0.05);血气分析:PaO_2、SaO_2及血清丙二醛含量在输注高氧液前两组间比较无差异(P>0.05),输注高氧液后各时间点治疗组和对照组比较PaO_2、SaO_2提高(P<0.05),血清丙二醛含量降低(P<0.05)。结论在重症烧伤早期输注高氧液是安全的、有效的,可提高患者的PaO_2、SaO_2,迅速改善组织细胞缺血缺氧,并且可减轻严重烧伤早期的脂质过氧化反应,减轻氧自由基损伤。 Objective To investigate the safety and efficacy of hyperoxic liquid infusion and its effect on serum malondialdehyde in patients with severe burn. Methods The patients were admitted to the hospital within 72 hours after injury and their total burns surface area (TBSA) was above 30%. There were 30 severe burns aged 18 to 65 years without severe illness before the operation and were randomly divided into treatment group and control group Group, 15 cases in each group. The two groups were treated according to the “four early” regimen. On the basis of this, the treatment group was infused with 500 ml × 4/24 h of hyperoxia liquid instead of the same amount of conventional liquid during the intravenous rehydration. The control group was infused with conventional liquid . Blood samples were collected before and 24 h, 48 h and 72 h after infusion of hyperoxic liquid in both groups, and the content of malondialdehyde in serum was measured by turbidimetry. Blood samples were collected at the same time point, the general situation of each case was recorded, including: body temperature, respiration, heart rate, arterial blood collected by the femoral artery blood gas analysis. Data to  ± s said, using PEMS 3.1 statistical analysis software for t test. Results The general situation of two groups of patients: body temperature, respiration, heart rate before and after infusion of hyperoxia liquid at all time points before and after no significant difference (P> 0.05); blood gas analysis: PaO_2, SaO_2 and serum malondialdehyde in infusion of high oxygen Compared with the control group, PaO_2 and SaO_2 were increased (P <0.05) and the level of malondialdehyde (MDA) was decreased (P <0.05) . Conclusions The infusion of hyperoxic liquid in the early stage of severe burn is safe and effective, which can improve PaO_2 and SaO_2 in patients and rapidly improve ischemia and hypoxia of tissue cells. It can also reduce the lipid peroxidation in the early stage of severe burn and reduce the oxygen free Basal injury.