单克隆抗体与肿瘤细胞的特异反应已为肿瘤抗原的研究提供了一种新方法,并在诊断中客观地识别瘤细胞提供了可能性。CaI 单克隆抗体(CaIMA)是鼠的 IgM 型抗体,系通过注射人喉癌细胞培养物衍生糖蛋白产生的。该抗体能与肿瘤 CaI 抗原决定簇起反应,与非肿瘤细胞则否。CaI 抗原能与 CaIMA 发生免疫沉淀反应,而且可用免疫过氧化酶技术检测多种人类肿瘤,并已成功地用于积液中良、恶性细胞的鉴别。本文提示,CaIMA 可适用于积 The specific reaction of monoclonal antibodies with tumor cells has provided a new method for the study of tumor antigens and offers the possibility of objectively identifying tumor cells in the diagnosis. The CaI monoclonal antibody (CaIMA) is a murine IgM type antibody produced by injection of human larynx cancer cell-derived glycoproteins. This antibody reacts with tumor CaI antigenic determinants, but not with nontumor cells. CaI antigens can immunoprecipitate with CaIMA, and can be used to detect a variety of human tumors using immunoperoxidase technology, and have been successfully used in the identification of benign and malignant cells in effusions. This article suggests that CaIMA can be applied to plot