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围产期HBV的母婴传播在慢性HBV感染中起查要作用。对母亲HBeAg阳性的婴儿联合应用乙型肝炎免疫球蛋白(HBIg)和乙型肝炎疫苗是预防HBV传播的安全有效的方法。然而接受该联合预防的婴儿仍有5～10％发展为短暂的抗原血症或慢性HBV携带状态。为研究该预防方法的确切效果,作者采用高度敏感的聚合酶链反应
Maternal-infant transmission of perinatal HBV plays a key role in chronic HBV infection. The combination of hepatitis B immunoglobulin (HBIg) and hepatitis B vaccine in mothers with HBeAg-positive infants is a safe and effective method of preventing HBV transmission. However, 5 to 10% of infants receiving the combination prevent development of transient antigenemia or chronic HBV status. To study the exact effect of this prophylaxis, the authors used a highly sensitive polymerase chain reaction