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目的：探讨肿瘤标记物假尿嘧啶核苷（ｐｓｅｕｄｏｕｒｉｄｉｎｅＰＤ，简称假尿苷）对卵巢癌的临床价值。方法：采用反相高效液相色谱法（ＨＰＬＣ）快速测定卵巢癌、良性卵巢肿瘤和正常对照妇女尿液的假尿苷和肌酐（ＵＲ）含量。结果：卵巢癌病人尿假尿苷／肌酐（ＰＤ／ＵＲ）显著高于良性卵巢肿瘤和正常对照者（Ｐ＜００１）。尿ＰＤ／ＵＲ在卵巢癌组的阳性率为９２８％，良性卵巢肿瘤组为１７４％，正常对照组无一例阳性。结论：测定尿ＰＤ／ＵＲ对卵巢癌的筛查、诊断和监测是一个简便易行、快速可靠的方法。
Objective: To investigate the clinical value of tumor marker pseudouridinePD in ovarian cancer. Methods: The contents of pseudouridine and creatinine (UR) in the urine of ovarian cancer, benign ovarian tumor and normal control women were rapidly determined by reversed-phase high performance liquid chromatography (HPLC). Results: Urinary uridine / creatinine (PD / UR) in patients with ovarian cancer was significantly higher than that in benign ovarian tumors and normal controls (P <001). The positive rate of urinary PD / UR was 92.8% in ovarian cancer group and 17.4% in benign ovarian tumor group, but no positive in normal control group. Conclusion: The detection of urinary PD / UR in ovarian cancer screening, diagnosis and monitoring is a simple, easy, fast and reliable method.