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目的比较三种不同杀菌方法治疗老年幽门螺杆菌(Hp)感染患者的疗效。方法将患者随机分为A组68例,B组70例和C组70例,分别给予序贯疗法、新三联疗法和标准三联疗法治疗。3组疗程均为10 d,停药4周后13C尿素呼气试验评估Hp根除率。结果 A、B、C组的Hp根除率分别为85.29%、80.00%和61.43%,A组Hp根除率显著高于B、C组,且与C组比较差异有统计学意义(P<0.01);B、C组Hp根除率比较差异亦有统计学意义(P<0.01);3组不良反应发生率比较差异无统计学意义(P>0.05)。结论 10 d序贯疗法、新三联及标准三联均能有效根除Hp感染,且无明显不良反应,但10 d序贯疗法效果更为显著。
Objective To compare the efficacy of three different sterilization methods in the treatment of elderly Helicobacter pylori (Hp) infection. Methods The patients were randomly divided into A group of 68 cases, B group of 70 cases and C group of 70 cases, were given sequential therapy, neo-triple therapy and standard triple therapy. Three groups of treatment were 10 d, 4 weeks after stopping drug evaluation of 13C urea breath test Hp eradication rate. Results The Hp eradication rates in groups A, B and C were 85.29%, 80.00% and 61.43%, respectively. The eradication rate of Hp in group A was significantly higher than that in group B and C (P <0.01) There was also a significant difference in Hp eradication rates between groups B and C (P <0.01). There was no significant difference in the incidence of adverse reactions among the three groups (P> 0.05). Conclusions 10 days of sequential therapy, triple therapy and triple therapy can effectively eradicate Hp infection with no obvious adverse reactions, but the 10-day sequential therapy is more effective.